The process of inflammation is very important as a response to cell stress, infection, or tissue damage; without inflammation, we would not recover from these insults. However, too much of a good thing can be bad, so if inflammation is left unchecked, it can cause damage and even death. In my day job, I am one of the editors of the scientific journal Science Signaling, and in the 3 March 2015 issue, we have a special focus on inflammation.
For this issue, I wrote an Editorial Guide that highlights recent published research that investigated the mechanisms that promote or resolve inflammation. A better understanding of the molecular players involved in the inflammatory response will result in the development of more effective therapies to treat acute and chronic inflammatory diseases, including sepsis, multiple sclerosis, and arthritis.