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John F. Foley

Science Signaling issue of September 8

1 min read

In the latest issue of Science Signaling, you can read research about how cancer-associated mutations in the E3 ubiquitin ligase RNF43 prevent it from inhibiting Wnt-beta-catenin signaling; how macrophages can promote atherosclerosis when an ion transporter is activated by a scavenger receptor bound to oxidized LDL; and how the combination of CRISPR and RNAi in a screen helps to identify drug targets. You can also listen to not one, but two Podcast interviews with researchers: one on RNF43 and Wnt signaling, the other on macrophages and atherosclerosis. In this week's Editors' Choice section, research on PI3K, TLRs, and Notch signaling are highlighted. Check out the table of contents here: http://stke.sciencemag.org/content/8/393