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John F. Foley

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John F. Foley

Test of quill editor

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Just trying again...

John F. Foley

Science Signaling: 9 February 2016 issue

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The latest issue of Science Signaling is now online. This week features one study on the phosphoproteomic analysis of interacting tumor cells and endothelial cells, which identified potential therapeutic targets involved in metastasis, and another research paper that showed how the distribution of a certain opioid receptor in the plasma membrane may underlie the different signaling outcomes that its stimuli, including morphine, elicit. A Review highlights the interplay between signaling research and synthetic biology, and how cells can be engineered with the minimal machinery to endow them with new behaviors and functions. As always, the Editors' Choice section features summaries of other signaling research papers of interest.

http://stke.sciencemag.org/content/9/414

John F. Foley

Science Signaling: 5 January 2016

1 min read

The first issue of Science Signaling of 2016 is out today, and with it comes our traditional look back at the studies that provided breakthroughs in signaling-related research in 2015. These include analyses of cell death mechanisms, insights into the pathogenesis or treatment of diseases such as cancer, and signals used by parasitic plants. You can also listen to a Podcast interview with Chief Scientific Editor Michael Yaffe and Editor Nancy Gough about the current state of signal transduction research. In addition, there are original research papers, including a study by Iain Fraser's group and collaborators on differences in signaling protein use exhibited by Toll-like receptors in human and mouse cells. Such analysis of conserved and species-specific use of signaling proteins could help in study and treatment of human autoimmune diseases. http://stke.sciencemag.org/content/9/409

John F. Foley

John F. Foley

Science Signaling issue of September 15

1 min read

In the September 15 issue of Science Signaling, you can read original research papers about how a G protein alpha-subunit mediates cellular proliferation stimulated by the Hedgehog effector Smoothened; how different classes of antigen receptors on the surface of B cells are organized in clusters and the way in which antigen stimulation alters this organization; and about how improving a protein-enrichment technique has enabled detailed analysis of protein phosphorylation patterns in bacteria. There is a Focus article on the Smoothened-G protein signaling axis, as well as editor-curated highlights of the recent literature, including a study of how neutrophils mediate the surgery-induced formation of tumors. http://stke.sciencemag.org/content/8/394

John F. Foley

Science Signaling issue of September 8

1 min read

In the latest issue of Science Signaling, you can read research about how cancer-associated mutations in the E3 ubiquitin ligase RNF43 prevent it from inhibiting Wnt-beta-catenin signaling; how macrophages can promote atherosclerosis when an ion transporter is activated by a scavenger receptor bound to oxidized LDL; and how the combination of CRISPR and RNAi in a screen helps to identify drug targets. You can also listen to not one, but two Podcast interviews with researchers: one on RNF43 and Wnt signaling, the other on macrophages and atherosclerosis. In this week's Editors' Choice section, research on PI3K, TLRs, and Notch signaling are highlighted. Check out the table of contents here: http://stke.sciencemag.org/content/8/393

John F. Foley

New issue of Science Signaling

1 min read

A new issue of Science Signaling is out. Read research about receptor complexes in plants and the role of ASK kinases in antiviral responses. http://stke.sciencemag.org/

John F. Foley

Perhaps I was pointing the camera the wrong way? [Test of comments from Quill]

John F. Foley

Looking the wrong way

Looking the wrong way

Penguins at the San Francisco Zoo in August 2014. Nikon F5. 300 mm f/4. HP5+ film.